Hydroxypropyl methylcellulosehe ahua o te cellulose kore-katote i konatunatua ether. Kaore i rite ki te katote methyl carboxymethyl cellulose i konatunatua ether, kaore e tauhohe ki nga konganuku taumaha. Na te rereke o nga rereketanga o te ihirangi methoxyl me te ihirangi hydroxypropyl i roto i te hydroxypropyl methylcellulose me nga rereke rereke, he maha nga momo me nga ahuatanga rereke, hei tauira, te nui o te methoxyl me te iti o te hydroxypropyl ihirangi Ko tana mahi e tata ana ki te methyl cellulose, i te mea ko te mahi o te iti methoxyl ihirangi me te hydroxypropyl hydroxylpropyllose teitei he tata. Heoi, i roto i ia momo, ahakoa he iti noa iho te roopu hydroxypropyl, he roopu methoxyl iti ranei kei roto, he nui nga rereketanga o te whakarewatanga i roto i nga whakarewa pararopi, i te pāmahana karekau ranei i roto i nga wairewa wai.
(1) Nga ahuatanga whakarewa o te hydroxypropyl methylcellulose
① Te wairewa o te hydroxypropyl methylcellulose ki te waiHydroxypropyl methylcellulosehe momo methylcellulose kua whakarereketia e te propylene oxide (methoxy-propylene), no reira he rite tonu nga ahuatanga ki te methyl cellulose he rite nga ahuatanga o te wairewa matao me te koretake o te wai wera. Heoi, na te roopu hydroxypropyl kua whakarereketia, he nui ake te pāmahana o te wai wera i tera o te methyl cellulose. Hei tauira, ko te viscosity o te wairewa wai hydroxypropyl methylcellulose me te 2% methoxy content substitution degree DS=0.73 me te hydroxypropyl content MS=0.46 he 500 mpa·s i te 20°C, me tona mahana rangi Ka taea te tata ki te 100°C, ko te methyl cellulose i te 55°C anake te pāmahana. Mo tona memehatanga ki te wai, kua tino pai ake. Hei tauira, ka taea te hoko mai i te hydroxypropyl methylcellulose (te ahua kowhatu 0.2~0.5mm i te 20°C me te 4% te pokey wairewa wai o te 2pa•s ka taea te hoko i te pāmahana rūma, he ngawari te rewa ki te wai me te kore e whakamatao.
② Te whakarewatanga o te hydroxypropyl methylcellulose i roto i nga whakarewa pararopi he pai ake hoki te whakarewatanga o te hydroxypropyl methylcellulose i roto i nga whakarewa pararopi i tera o te methylcellulose. Ko te Methylcellulose me whai tohu methoxyl substitution o 2.1 Ko nga hua o runga ake nei, engari kei roto te hydroxypropyl MS=1.5~1.8 me te methoxy DS=0.2~1.0, te hydroxypropyl methylcellulose teitei-nui me te tohu katoa o te whakakapinga i runga ake i te 1.8 ka rewa i roto i te wairewa waikore me te hauwai-waiwai, me te wairewa hauwai me te hauwai. whakarewatanga. He wairewa ano i roto i nga waiwaro maataa penei i te methylene chloride me te chloroform, me nga whakarewa waro penei i te acetone, isopropanol me te waipiro diacetone. He pai ake te whakarewatanga o te wairewa i te wairewa.
(2) Nga mea e Whakaawe ana i te Viscosity o Hydroxypropyl Methyl Cellulose Ko te whakatau i te viscosity paerewa o te hydroxypropyl methyl cellulose he rite tonu ki era atu etera cellulose. Ka ine ki te 20°C me te 2% wairewa wai hei paerewa. Ko te pokey o taua hua ka piki ake me te piki o te kukū. Mo nga hua he rereke nga taumahatanga ngota i te kukū kotahi, ko te hua he nui ake te taumaha ngota he nui ake te pokey. Ko tona hononga ki te pāmahana he rite ki te methyl cellulose. Ka piki ake te pāmahana, ka timata te heke o te pokey, engari ka tae ki tetahi pāmahana, ka piki ohorere te pokey, ka puta te wai. He teitei ake te mahana o te reera o nga hua iti-viscosity. he tiketike. Ko tana tohu gel e kore e pa ana ki te pokey o te ether anake, engari e pa ana ki te ōwehenga hanganga o te roopu methoxyl me te roopu hydroxypropyl i roto i te ether me te rahi o te tohu whakakapinga katoa. Me tohu ko te hydroxypropyl methylcellulose he pseudoplastic hoki, a ka pumau tana otinga i te pāmahana rūma kaore he paheketanga o te pokey engari mo te tupono o te whakahekenga enzymatic.
(3) Ko te manawanui o te tote o te hydroxypropyl methylcellulose I te mea ko te hydroxypropyl methylcellulose he etera kore-katote, kaore i te katote i roto i nga papaaho wai, kaore i rite ki etahi atu ethers cellulose katote, penei i te carboxymethyl Base cellulose, i roto i te otinga ki te tauhohe ki nga katote whakarewa taimaha me te whakaheke. Ko nga tote whanui penei i te chloride, bromide, Phosphate, nitrate, me etahi atu e kore e mimiti ina tapirihia ki tana wairewa wai. Heoi ano, ko te taapiri o te tote he awe ki runga i te pawera o te wairewa wai. Ka piki ake te kukū o te tote, ka heke te pāmahana reera. I te mea kei raro te kukū o te tote i te tohu kapo, ka piki ake te pokey o te otinga. Na reira, ka tapiritia he nui o te tote, i roto i te tono, ka taea e ia te whakatutuki i te kaha o te kaha ohaoha. Na reira, i roto i etahi tono, he pai ake te whakamahi i te ranunga o te cellulose ether me te tote atu i te kukū teitei ake o te otinga ether ki te whakatutuki i te paanga matotoru.
(4) Hydroxypropyl methylcellulose acid and alkali resistance Hydroxypropyl methylcellulose is commonly stable to acids and alkalis, and is not affect in the range of pH 2~12. Ka taea e ia te tu atu i te nui o te waikawa marama, Pērā i te waikawa formic, te waikawa acetic, te waikawa citric, te waikawa succinic, te waikawa phosphoric, te waikawa boric, me etahi atu. Engari ko te waikawa kukū te hua o te whakaiti i te pokey. Karekau he painga ki runga i te wai kawa, penei i te houra, te paura wai me te kotakota, engari ka taea te whakanui ake i te pokey o te otinga, katahi ka ata heke iho.
(5) Ko te koretake o te wairewa hydroxypropyl methylcellulose Hydroxypropyl methylcellulose ka taea te konatunatua ki te wai-wairewa polymer pūhui kia noho rite, kia marama te otinga me te pokey teitei ake. Ko enei pūhui polymer ko te polyethylene glycol, polyvinyl acetate, polysilicone, polymethylvinyl siloxane, hydroxyethyl cellulose, me te methyl cellulose. He pai hoki te hototahitanga o nga puhui irapoi teitei penei i te kapia arabic, te kapia mawhitiwhiti, te kapia karaya, me etahi atu. Ko te Hydroxypropyl methylcellulose ka taea ano te whakauru ki te mannitol ester, sorbitol ester ranei o te waikawa stearic, te waikawa palmitic ranei, ka taea hoki te whakauru ki te glycerin, te sorbitol me te mannitol, a ka taea te whakamahi i enei pūhui hei Plasticizer hydroxypropyl methylcellulose mo te cellulose.
(6) Ko te wai-wairewa-koreethers celluloseKa taea e te hydroxypropyl methylcellulose te kawe i te hononga-whakawhitinga mata ki te aldehydes, na enei etera wairewa-wai ka heke i roto i te wairewa ka kore e rewa ki te wai. Ko nga aldehydes e hanga ana i te hydroxypropyl methylcellulose kia kore e rewa ko formaldehyde, glyoxal, succinic aldehyde, adipaldehyde, me etahi atu. Ina whakamahi formaldehyde, me aro nui ki te uara pH o te otinga, i roto i te tere o te urupare a te glyoxal, na reira ka whakamahia te glyoxal hei kaihoko whakawhiti ahumahi. Ko te inenga o tenei ahua o te kaihoko whakawhiti i roto i te otinga ko te 0.2% ~ 10% o te papatipu o te ether, he pai ki te 7% ~ 10%, hei tauira, ko te 3.3% ~ 6% o te glyoxal te mea tino pai. Ko te tikanga, ko te pāmahana maimoatanga ko 0 ~ 30 ℃, me te wa ko 1 ~ 120min. Me whakahaere te tauhohenga whakawhiti i raro i nga tikanga waikawa. Ko te tikanga, ka whakatikahia te pH o te otinga ki te 2~6 ma te taapiri i te waikawa kaha pararopi, te waikawa warokarota waro ranei ki te otinga, he pai ki waenga i te 4~6, katahi ka taapirihia nga aldehydes hei kawe i te tauhohenga whakawhiti. Ko te waikawa i whakamahia he waikawa waikawa, he waikawa pungatara, he waikawa phosphoric, he waikawa formic, he waikawa acetic, he waikawa-waikawa, he waikawa succinic, he waikawa citric me etahi atu. Ka taea hoki te taapiri i te waikawa me te aldehyde i te wa kotahi ki te tuku i te otinga kia uru ki te tauhohenga honohono i roto i te awhe pH e hiahiatia ana. Ka whakamahia tenei tauhohenga i roto i te tukanga maimoatanga whakamutunga i roto i te whakaritenga o nga eter cellulose. I muri i te koretake o te cellulose ether, he pai ki te whakamahi.
20~25 ℃ wai mo te horoi me te purenga. I te wa e whakamahia ana te hua, ka taea te taapiri i nga matū kawakore ki te otinga o te hua hei whakatika i te pH o te otinga kia kawakore, ka tere te memeha o te hua ki te otinga. Ko tenei tikanga e pa ana ki te maimoatanga o te kiriata i muri i te hanga o te otinga cellulose ether hei kiriata kia waiho hei kiriata korekore.
(7) Ko te parenga o te enzyme o te hydroxypropyl methylcellulose ko nga hua o te cellulose, penei i ia roopu anhydroglucose, ki te mea he roopu whakakapi e mau ana, ehara i te mea ngawari ki te pangia e te microorganisms, engari ko te hua kua oti ka nui ake i te 1 te uara whakakapinga, ka whakahekehia ano e te roopu o te roopu o te roopu, ko te tikanga ka kore e rite ki te waahanga o te roopu o te roopu, ko te tikanga ko te mea kua oti te hua ka nui atu i te 1, ka whakahekehia ano e te roopu o te roopu, ko te tikanga he nui te waahanga o te roopu o te roopu. a ka taea e nga microorganisms te horo i runga i te roopu anhydroglucose kaore i whakakapia ki te hanga huka, hei matūkai mo nga microorganisms ki te horo. No reira, ki te piki ake te tohu o te whakakapinga whakaeera o te cellulose, ka piki ano te aukati ki te horo enzymatic o te cellulose ether. E ai ki nga purongo, i raro i nga tikanga whakahaere, ko nga hua o te hauwai o nga enzyme i hangaia, ko te toenga o te kirikiri o te hydroxypropyl methylcellulose (DS=1.9) he 13.2%, ko te methylcellulose (DS=1.83) he 7.3%, ko te methylcellulose (DS=1.66) he 3.8%, me te hydroxyethyl1%. Ka kitea he kaha te kaha o te hydroxypropyl methylcellulose ki te anti-enzyme. Na reira, ko te tino pai o te aukati o te waikawa o te hydroxypropyl methylcellulose, me te pai o te whakamararatanga, te matotoru me te hanga kiriata, ka whakamahia i roto i nga paninga wai-emulsion, me etahi atu, me te nuinga kaore e hiahia ki te taapiri i nga rongoa. Engari, mo te wa roa mo te rokiroki o te otinga, ka taea ranei te poke mai i waho, ka taea te taapiri i nga whakamarumaru hei whakatupato, a ka taea te whakatau i te whiringa i runga i nga whakaritenga whakamutunga o te otinga. Ko te Phenylmercuric acetate me te manganese fluorosilicate he rongoa whai hua, engari kei a raatau katoa te Toxicity, me aro ki te mahi. Ko te tikanga, ka taea te taapiri 1~5mg o te phenylmercury acetate ki te otinga mo ia rita o te inenga.
(8) Mahinga ohydroxypropyl methylcellulosekiriata Hydroxypropyl methylcellulose he pai rawa nga ahuatanga hanga kiriata. Ka whakakikoruatia tana wairewa wai, he wairewa pararopi ranei ki runga i te pereti karaihe, ka kore te tae, ka marama i muri i te whakamaroketanga. Me te kiriata uaua. He pai te aukati makuku me te pumau tonu i nga wera teitei. Mena ka taapirihia te whakamaarama hygroscopic, ka taea te whakaroa me te ngawari. I runga i te whakapai ake i te ngawari, ko nga kaiparapara penei i te glycerin me te sorbitol te mea tino pai. Ko te tikanga, ko te kukū otinga ko 2% ~ 3%, me te nui o te plasticizer ko 10% ~ 20% o te cellulose ether. Mena he tiketike rawa te ihirangi o te plasticizer, ka paheke te paheketanga colloidal i te makuku nui. Ko te kaha tensile o te kiriata me te plasticizer taapiri he nui ake i tera kaore he kirihou, ka piki ake ki te piki o te moni taapiri. Mo te hygroscopicity o te kiriata, ka piki ake ano me te piki o te nui o te plasticizer.
Te wa tuku: Apr-25-2024