Cov dej noo ntawm HPMC yog dab tsi?

Hydroxypropyl Methylcellulose (HPMC)yog cov dej-soluble polymer feem ntau siv hauv kev lag luam tshuaj, zaub mov, tshuaj pleev ib ce, thiab kev tsim kho kev lag luam. Cov dej noo ntawm HPMC ua lub luag haujlwm tseem ceeb hauv nws txoj kev ua haujlwm thiab kev ruaj ntseg. Nws cuam tshuam cov khoom rheological, solubility, thiab txee lub neej ntawm cov khoom. Nkag siab txog cov ntsiab lus ntawm cov dej noo yog qhov tseem ceeb rau nws txoj kev tsim, khaws cia, thiab siv qhov kawg.

Moisture Content ntawm HPMC

Cov dej noo ntawm AnxinCel®HPMC feem ntau txiav txim siab los ntawm cov txheej txheem txheej txheem thiab qib tshwj xeeb ntawm cov khoom siv polymer. Cov dej noo tuaj yeem sib txawv nyob ntawm cov khoom siv raw, khaws cia, thiab txheej txheem ziab. Nws feem ntau yog qhia raws li feem pua ​​​​ntawm qhov hnyav ntawm cov qauv ua ntej thiab tom qab ziab. Rau cov ntawv thov kev lag luam, cov ntsiab lus noo noo yog qhov tseem ceeb, vim tias cov dej noo ntau dhau tuaj yeem ua rau degradation, clumping, lossis txo kev ua haujlwm ntawm HPMC.

Cov dej noo ntawm HPMC tuaj yeem nyob ntawm 5% mus rau 12%, txawm tias qhov sib txawv ntawm 7% thiab 10%. Cov dej noo tuaj yeem txiav txim siab los ntawm kev ziab cov qauv ntawm qhov kub thiab txias (piv txwv li, 105 ° C) kom txog thaum nws nce mus txog qhov hnyav tas li. Qhov sib txawv ntawm qhov hnyav ua ntej thiab tom qab ziab yog cov ntsiab lus noo noo.

Cov yam ntxwv cuam tshuam rau cov dej noo hauv HPMC

Ntau yam tuaj yeem cuam tshuam cov dej noo ntawm HPMC:

Humidity thiab Storage Conditions:

Cov av noo siab lossis kev cia khoom tsis zoo tuaj yeem ua kom cov dej noo ntawm HPMC.

HPMC yog hygroscopic, txhais tau tias nws nyiam nqus dej los ntawm cov huab cua ib puag ncig.

Ntim thiab sealing ntawm cov khoom tuaj yeem txo qhov nqus dej tsawg.

Txheej Txheem Txheej Txheem:

Kev ziab kom qhuav thiab lub sijhawm thaum lub sijhawm tsim khoom tuaj yeem cuam tshuam cov ntsiab lus noo noo kawg.

Kev ziab sai sai tuaj yeem ua rau cov dej seem seem, thaum ziab qeeb yuav ua rau cov dej noo ntau ntxiv.

HPMC Qib:

Cov qib sib txawv ntawm HPMC (piv txwv li, qis viscosity, nruab nrab viscosity, lossis siab viscosity) yuav muaj qhov sib txawv me ntsis vim qhov sib txawv ntawm cov qauv molecular thiab kev ua haujlwm.

Supplier Specifications:

Cov neeg xa khoom tuaj yeem muab HPMC nrog cov ntsiab lus noo noo uas ua raws li cov qauv kev lag luam.

Hom Moisture Content ntawm HPMC los ntawm Qib

Cov dej noo ntawm HPMC sib txawv nyob ntawm qib thiab qhov xav tau siv. Ntawm no yog ib lub rooj uas qhia txog cov dej noo ib txwm muaj rau cov qib sib txawv ntawm HPMC.

Kev ntsuam xyuas thiab kev txiav txim siab ntawm cov dej noo

Muaj ntau txoj hauv kev los txiav txim siab cov dej noo ntawm HPMC. Ob txoj kev uas feem ntau yog:

Gravimetric Method (Poob rau ziab, LOD):

Qhov no yog txoj kev siv dav tshaj plaws los txiav txim siab cov dej noo. Ib qho hnyav ntawm HPMC tau muab tso rau hauv qhov cub kom qhuav ntawm 105 ° C. Tom qab lub sijhawm teev tseg (feem ntau yog 2-4 teev), tus qauv raug hnyav dua. Qhov sib txawv ntawm qhov hnyav muab cov ntsiab lus noo noo, uas yog qhia raws li feem pua ​​​​ntawm thawj qhov hnyav.

Karl Fischer Titration:

Txoj kev no yog qhov tseeb dua li LOD thiab koom nrog cov tshuaj tiv thaiv uas ntsuas cov ntsiab lus dej. Txoj kev no feem ntau yog siv thaum muaj kev txiav txim siab noo noo xav tau.

Kev cuam tshuam ntawm cov dej noo ntawm HPMC Cov Khoom

Cov dej noo ntawm AnxinCel®HPMC cuam tshuam nws cov kev ua tau zoo hauv ntau daim ntawv thov:

viscosity:Cov dej noo tuaj yeem cuam tshuam qhov viscosity ntawm HPMC cov kev daws teeb meem. Cov dej noo ntau dua tuaj yeem ua rau muaj viscosity hauv qee cov qauv, thaum cov dej noo qis tuaj yeem ua rau qis viscosity.

Solubility:Cov dej noo ntau dhau tuaj yeem ua rau agglomeration lossis txo cov solubility ntawm HPMC hauv dej, ua rau nws tsis zoo rau qee yam kev siv, xws li kev tswj kev tso tawm formulations hauv kev lag luam kws tshuaj.

Kev ruaj ntseg:HPMC feem ntau ruaj khov nyob rau hauv qhuav tej yam kev mob, tab sis siab noo noo cov ntsiab lus yuav ua rau microbial loj hlob los yog tshuaj degradation. Vim li no, HPMC feem ntau yog khaws cia rau hauv cov thawv kaw hauv qhov chaw tsis muaj av noo.

Cov ntsiab lus noo noo thiab ntim ntawm HPMC

Vim yog qhov xwm txheej hygroscopic ntawm HPMC, kev ntim khoom tsim nyog yog qhov tseem ceeb los tiv thaiv kev nqus dej los ntawm huab cua. HPMC feem ntau yog ntim rau hauv cov hnab ntim dej los yog cov thawv ntim khoom xws li polyethylene lossis ntau txheej laminates los tiv thaiv cov av noo. Lub ntim kom ntseeg tau tias cov dej noo nyob hauv qhov xav tau ntau yam thaum khaws cia thiab thauj.

Moisture Content Control nyob rau hauv Manufacturing

Thaum lub sij hawm tsim khoom ntawm HPMC, nws yog ib qho tseem ceeb uas yuav tsum tau saib xyuas thiab tswj cov dej noo kom tswj tau cov khoom zoo. Qhov no tuaj yeem ua tiav los ntawm:

Tshuab ziab khaub ncaws:HPMC tuaj yeem qhuav siv cua kub, tshuab nqus tsev, lossis tshuab ziab khaub ncaws. Qhov kub thiab lub sij hawm ziab yuav tsum tau ua kom zoo kom tsis txhob qhuav qhuav (cov ntsiab lus noo noo siab) thiab qhuav dhau (uas yuav ua rau thermal degradation).

Environmental Control:Kev tswj hwm ib puag ncig nrog cov av qis hauv thaj chaw tsim khoom yog qhov tseem ceeb. Qhov no tuaj yeem koom nrog dehumidifiers, cua txias, thiab siv cov ntsuas dej noo los saib xyuas cov huab cua thaum ua haujlwm.

Cov dej noo ntawm HPMCfeem ntau ntog hauv thaj tsam ntawm 7% mus rau 10%, txawm hais tias nws tuaj yeem sib txawv nyob ntawm qib, daim ntawv thov, thiab kev cia khoom. Cov ntsiab lus noo noo yog qhov tseem ceeb uas cuam tshuam rau cov khoom rheological, solubility, thiab stability ntawm AnxinCel®HPMC. Cov neeg tsim khoom thiab cov neeg tsim khoom yuav tsum ua tib zoo tswj thiab saib xyuas cov dej noo kom ntseeg tau tias kev ua tau zoo hauv lawv cov kev siv tshwj xeeb.