Hydroxypropyl Methylcellulose (HPMC) yog ntau yam polymer siv nyob rau hauv ntau yam lag luam xws li tshuaj, kev tsim kho, khoom noj khoom haus, thiab tshuaj pleev ib ce. Nws yog muab los ntawm cellulose, ib tug natural polymer nyob rau hauv cov nroj tsuag. HPMC tau txais txiaj ntsig zoo rau nws cov yeeb yaj kiab tsim, thickening, stabilizing, thiab dej tuav cov khoom. Hauv kev lag luam kws tshuaj, nws feem ntau yog siv los ua cov khoom siv tshuaj hauv qhov ncauj ntau npaum li cas, kev npaj kho qhov muag, cov tshuaj pleev ib ce, thiab tswj-tso tshuaj xa cov tshuab.
HPMC tuaj yeem raug cais raws li ntau yam tsis suav nrog nws qhov hnyav molecular, qib hloov pauv, thiab qhov loj me. Nov yog cov lus piav qhia ntawm ntau hom HPMC raws li cov kev txwv no:
Raws li Molecular Luj:
High Molecular Nyhav HPMC: Hom HPMC no muaj qhov hnyav dua molecular, ua rau txhim kho viscosity thiab zaj duab xis-tsim zog. Nws feem ntau nyiam nyob rau hauv cov ntawv thov uas yuav tsum tau muaj viscosity siab dua, xws li hauv kev tswj-tso formulations.
Tsawg Molecular Nyhav HPMC: Hloov pauv, qhov hnyav molecular HPMC muaj qis dua viscosity thiab yog siv rau hauv cov ntawv thov uas qis dua viscosity thiab nrawm dua yog xav tau.
Raws li Degree of Substitution (DS):
Kev hloov pauv siab HPMC (HPMC-HS): HPMC nrog kev hloov pauv siab feem ntau pom zoo solubility hauv dej thiab tuaj yeem siv rau hauv cov qauv uas yuav tsum tau tawg sai.
Kev Hloov Nruab Nrab HPMC (HPMC-MS): Hom HPMC no muab qhov sib npaug ntawm solubility thiab viscosity. Nws yog feem ntau siv nyob rau hauv ntau yam tshuaj formulations.
Tsawg Hloov HPMC (HPMC-LS): HPMC nrog qib qis ntawm kev hloov pauv muaj qhov sib cais qeeb dua thiab muaj viscosity ntau dua. Nws yog feem ntau siv nyob rau hauv sustained-tso cov ntaub ntawv ntau npaum.
Raws li Particle Loj:
Fine Particle Size HPMC: HPMC nrog cov khoom me me muaj cov khoom ntws zoo dua thiab feem ntau nyiam nyob rau hauv cov ntaub ntawv ntau npaum li cov ntsiav tshuaj thiab tshuaj ntsiav.
Coarse Particle Size HPMC: Coarser hais yog tsim rau cov ntawv thov uas tswj kev tso tawm lossis txuas ntxiv-tso cov khoom xav tau. Lawv feem ntau siv hauv cov ntsiav tshuaj matrix thiab pellets.
Cov Qib Tshwj Xeeb:
Enteric HPMC: Hom HPMC no tshwj xeeb tsim los tiv thaiv cov kua hauv plab, ua kom nws hla lub plab kom zoo thiab tso cov tshuaj hauv txoj hnyuv. Nws yog feem ntau siv rau cov tshuaj rhiab heev rau plab pH lossis rau kev xa khoom.
Sustained Release HPMC: Cov qauv no yog tsim los tso tawm cov khoom xyaw nquag maj mam dhau lub sijhawm ntev, ua rau lub sijhawm ntev ntawm kev siv tshuaj thiab txo cov koob tshuaj ntau zaus. Lawv feem ntau siv nyob rau hauv cov mob ntev uas tswj cov qib tshuaj tas li hauv cov ntshav yog qhov tseem ceeb.
Combination Qib:
HPMC-Acetate Succinate (HPMC-AS): Hom HPMC no sib txuas cov khoom ntawm HPMC thiab acetyl pawg, ua rau nws haum rau cov txheej txheej enteric thiab pH-sensitive tshuaj xa cov tshuab.
HPMC-Phthalate (HPMC-P): HPMC-P yog pH-dependent polymer feem ntau siv nyob rau hauv enteric coatings los tiv thaiv cov tshuaj los ntawm acidic tej yam kev mob nyob rau hauv lub plab.
Customized Blends:
Cov neeg tsim khoom tuaj yeem tsim cov kev sib xyaw ua ke ntawm HPMC nrog lwm cov khoom siv polymers lossis cov khoom siv ntxiv kom ua tiav cov kev cai tshwj xeeb xws li kev txhim kho cov tshuaj tso tawm cov ntaub ntawv, txhim kho kev ruaj ntseg, lossis zoo dua saj-masking zog.
Cov khoom sib txawv ntawm HPMC tso cai rau nws siv nyob rau hauv ntau yam ntawm cov tshuaj formulations, txhua tailored kom tau raws li cov kev cai tshwj xeeb xws li solubility, viscosity, tso tawm kinetics, thiab stability. Kev nkag siab txog ntau hom HPMC thiab lawv cov yam ntxwv yog qhov tseem ceeb rau cov kws tsim qauv los tsim cov tshuab xa tshuaj zoo thiab ua kom zoo.
Post lub sij hawm: Mar-19-2024