Hydroxypropyl Methylcellulose (HPMC)yog ib qho dej-soluble polymer feem ntau siv hauv kev lag luam tshuaj, tshuaj pleev ib ce thiab zaub mov. Vim nws cov dej solubility zoo heev thiab viscosity hloov kho cov khoom, HPMC yog dav siv nyob rau hauv gels, tshuaj tswj kev tso tawm cov ntaub ntawv, ncua kev kawm ntawv, thickeners thiab lwm yam teb. Ntau hom thiab cov kev qhia tshwj xeeb ntawm HPMC muaj qhov sib txawv ntawm qhov kub thiab txias, tshwj xeeb tshaj yog thaum npaj HPMC gels, qhov kub thiab txias muaj qhov tseem ceeb ntawm nws cov solubility, viscosity thiab stability.
HPMC dissolution thiab gel tsim kub ntau yam
Dissolution kub
HPMC feem ntau yog yaj nyob rau hauv dej nrog dej kub, thiab qhov kub dissolution nyob ntawm nws qhov hnyav molecular thiab qib ntawm methylation thiab hydroxypropylation. Feem ntau hais lus, qhov kub dissolution ntawm HPMC thaj tsam ntawm 70 ° C mus rau 90 ° C, thiab qhov tshwj xeeb dissolution kub yog cuam tshuam los ntawm cov specifications ntawm HPMC thiab cov concentration ntawm cov tshuaj. Piv txwv li, HPMC tsawg-viscosity feem ntau yaj ntawm qhov kub qis dua (kwv yees li 70 ° C), thaum lub siab-viscosity HPMC yuav xav tau qhov kub siab dua (ze li 90 ° C) kom yaj tag.
Gel Formation Temperature (Gelation Temperature)
HPMC muaj ib qho tshwj xeeb thermoreversible gel khoom, uas yog, nws yuav tsim ib tug gel nyob rau hauv ib tug tej yam kub kub. Qhov kub ntau ntawm HPMC gel feem ntau cuam tshuam los ntawm nws qhov hnyav molecular, cov qauv tshuaj, tshuaj concentration thiab lwm yam khoom ntxiv. Feem ntau hais lus, qhov kub ntawm HPMC gel feem ntau yog 35 ° C txog 60 ° C. Nyob rau hauv ntau qhov no, HPMC cov saw hlau molecular yuav rov ua dua los ua ib qho kev sib txuas ntawm peb sab, ua rau cov kev daws teeb meem hloov pauv ntawm lub xeev ua kua rau lub xeev gel.
Qhov tshwj xeeb gel tsim kub (piv txwv li, gelation kub) tuaj yeem txiav txim siab sim. Qhov kub thiab txias ntawm HPMC gel feem ntau yog nyob ntawm cov hauv qab no:
Molecular Luj: HPMC nrog qhov hnyav molecular tuaj yeem tsim cov gel ntawm qhov kub thiab txias.
Kev daws teeb meem: Qhov siab dua qhov kev daws teeb meem, qhov qis dua qhov gel tsim kub yog feem ntau.
Qib ntawm methylation thiab qib ntawm hydroxypropylation: HPMC nrog qib siab ntawm methylation feem ntau tsim cov gel ntawm qhov kub thiab txias vim tias methylation nce kev sib cuam tshuam ntawm cov molecules.
Cov nyhuv ntawm qhov kub thiab txias
Hauv kev siv cov tswv yim, qhov kub thiab txias muaj qhov cuam tshuam loj rau kev ua haujlwm thiab kev ruaj ntseg ntawm HPMC gel. Cov kub siab dua ua rau cov kua dej ntawm HPMC cov saw hlau molecular, yog li cuam tshuam rau cov rigidity thiab solubility yam ntxwv ntawm cov gel. Ntawm qhov tsis sib xws, qhov kub qis yuav ua rau lub cev tsis muaj dej ntawm HPMC gel thiab ua rau cov qauv gel tsis ruaj khov. Tsis tas li ntawd, kev hloov pauv kub kuj tseem tuaj yeem ua rau muaj kev cuam tshuam ntawm HPMC cov molecules thiab kev hloov pauv hauv viscosity ntawm cov tshuaj.
HPMC gelation tus cwj pwm ntawm pH sib txawv thiab ionic zog
Tus cwj pwm gelation ntawm HPMC cuam tshuam tsis yog los ntawm qhov kub thiab txias, tab sis kuj los ntawm pH thiab kev daws teeb meem ionic zog. Piv txwv li, kev solubility thiab gelation cwj pwm ntawm HPMC ntawm cov pH sib txawv yuav txawv. Lub solubility ntawm HPMC yuav raug txo nyob rau hauv acidic ib puag ncig, thaum nws solubility yuav nce nyob rau hauv alkaline ib puag ncig. Ib yam li ntawd, kev nce hauv ionic zog (xws li ntxiv ntsev) yuav cuam tshuam rau kev sib cuam tshuam ntawm HPMC molecules, yog li hloov qhov tsim thiab ruaj khov ntawm cov gel.
Daim ntawv thov ntawm HPMC gel thiab nws cov yam ntxwv kub
Cov yam ntxwv kub ntawm HPMC gel ua rau nws siv dav hauv kev tso tshuaj, tshuaj pleev ib ce thiab lwm yam haujlwm:
Tswj tshuaj tso tawm
Hauv kev npaj tshuaj, HPMC feem ntau yog siv los tswj kev tso tawm matrix, thiab nws cov khoom siv gelation yog siv los tswj cov tshuaj tso tawm. Los ntawm kev kho qhov concentration thiab gelation kub ntawm HPMC, qhov kev tso tawm ntawm cov tshuaj tuaj yeem tswj tau qhov tseeb. Qhov kub hloov ntawm cov tshuaj nyob rau hauv lub plab zom mov tuaj yeem txhawb qhov o ntawm HPMC gel thiab maj mam tso cov tshuaj.
Cov khoom siv tshuaj pleev ib ce thiab kho tus kheej
HPMC feem ntau siv rau hauv cov tshuaj pleev ib ce xws li tshuaj pleev, gels, tshuaj pleev plaub hau, thiab tshuaj pleev ib ce. Vim nws qhov kub thiab txias, HPMC tuaj yeem kho qhov kev ntxhib los mos thiab ruaj khov ntawm cov khoom nyob rau hauv qhov sib txawv kub. Kev hloov pauv kub hauv cov qauv tshuaj pleev ib ce muaj txiaj ntsig zoo rau kev coj tus cwj pwm gelation ntawm HPMC, yog li HPMC cov ntsiab lus tsim nyog yuav tsum tau ua tib zoo xaiv thaum tsim cov khoom.
Kev lag luam zaub mov
Hauv cov khoom noj, HPMC yog dav siv los ua cov thickener thiab emulsifier, tshwj xeeb tshaj yog nyob rau hauv cov khoom noj thiab dej haus. Nws cov khoom kub-rhiab heev ua rau HPMC hloov nws lub cev lub cev thaum lub sijhawm cua sov lossis txias, yog li cuam tshuam rau saj thiab qauv ntawm cov zaub mov.
Cov khoom kub ntawmHPMCgels yog qhov tseem ceeb hauv lawv daim ntawv thov. Los ntawm kev kho qhov kub thiab txias, concentration, thiab tshuaj hloov kho, cov khoom ntawm HPMC gels, xws li solubility, gel zog, thiab ruaj khov, tuaj yeem tswj tau meej. Qhov kub tsim gel feem ntau yog nyob nruab nrab ntawm 35 ° C thiab 60 ° C, thaum nws qhov kub thiab txias yog feem ntau 70 ° C txog 90 ° C. HPMC tau siv dav hauv kev lag luam tshuaj, tshuaj pleev ib ce, thiab khoom noj khoom haus vim nws qhov tshwj xeeb thermoreversible gelation tus cwj pwm thiab kub rhiab heev.
Post lub sij hawm: Jan-16-2025