Kev npaj ntawm Hydroxypropyl Methylcellulose

Hydroxypropyl Methylcellulose (HPMC)yog ib qho dej-soluble polymer compound tau los ntawm chemically modifying natural cellulose. Nws yog tsuas yog siv rau hauv kev lag luam tshuaj, khoom noj, tshuaj pleev ib ce, thiab kev tsim kho, thiab muaj cov khoom zoo xws li thickening, film-forming, emulsification, thiab stability.

1. Txoj hauv kev npaj

Hydroxypropyl methylcellulose yog hydrophilic cellulose derivative, thiab nws solubility feem ntau cuam tshuam los ntawm hydroxypropyl thiab methyl substituents nyob rau hauv molecule. Cov pab pawg methyl nce nws cov dej solubility, thaum pab pawg hydroxypropyl nce nws cov kev sib cais hauv dej. Feem ntau, AnxinCel®HPMC tuaj yeem yaj sai sai hauv dej txias los tsim cov tshuaj colloidal zoo li qub, tab sis dissolves maj mam hauv dej kub, thiab cov khoom siv granular yog qhov yooj yim rau kev sib sau ua ke thaum sib tov. Yog li ntawd, kev saib xyuas yuav tsum tau them nyiaj rau kev tswj qhov kub thiab txias ntawm kev sib cais thaum lub sij hawm npaj.

2. Raw khoom npaj

HPMC hmoov: Xaiv HPMC hmoov nrog sib txawv viscosities thiab qib hloov raws li qhov yuav tsum tau siv. Cov qauv muaj xws li cov viscosity tsawg (qhov hnyav molecular) thiab siab viscosity (siab molecular hnyav). Kev xaiv yuav tsum yog raws li qhov xav tau ntawm cov qauv tsim tshwj xeeb.

Cov kuab tshuaj: Dej yog cov kuab tshuaj siv ntau tshaj plaws, tshwj xeeb tshaj yog siv tshuaj thiab khoom noj. Raws li cov kev xav tau ntawm kev sib cais, kev sib xyaw ntawm cov dej thiab cov kuab tshuaj organic, xws li ethanol / dej sib tov, kuj tuaj yeem siv.

3. Txoj kev npaj

Qhov hnyav HPMC
Ua ntej, raug ntsuas qhov xav tau HPMC hmoov raws li qhov concentration ntawm cov tshuaj yuav tsum tau npaj. Feem ntau, qhov concentration ntau ntawm HPMC yog 0.5% mus rau 10%, tab sis qhov tshwj xeeb concentration yuav tsum tau kho raws li lub hom phiaj thiab qhov xav tau viscosity.

Pre-wetting dissolution
Txhawm rau tiv thaiv HPMC hmoov los ntawm agglomerating, pre-wetting dissolution feem ntau yog saws. Kev ua haujlwm tshwj xeeb yog: nphoo cov hmoov HPMC hnyav sib npaug rau hauv ib feem ntawm cov kuab tshuaj, do maj mam, thiab ua rau HPMC hmoov sib cuag nrog me me ntawm cov kuab tshuaj ua ntej los tsim lub xeev ntub dej. Qhov no tuaj yeem tiv thaiv HPMC hmoov los ntawm agglomerating thiab txhawb nws cov dispersion zoo.

Cov txheej txheem tawg
Maj mam ntxiv cov kuab tshuaj ntxiv rau cov hmoov HPMC ntub thiab txuas ntxiv stirring. Txij li thaum HPMC muaj dej solubility zoo, dej thiab HPMC yaj sai sai ntawm chav tsev kub. Tsis txhob siv lub zog shear siab dhau lawm thaum nplawm, vim tias muaj zog nplawm yuav ua rau cov npuas tsim, cuam tshuam rau cov pob tshab thiab sib xws ntawm cov tshuaj. Nyob rau hauv dav dav, lub stirring ceev yuav tsum tau khaws cia nyob rau hauv ib tug tsawg ntau yam kom ntseeg tau tias uniform dissolution.

Kev tswj qhov kub thiab txias
Txawm hais tias HPMC tuaj yeem yaj hauv dej txias, yog tias qhov kev sib cais qeeb qeeb, cov tshuaj tuaj yeem ua kom sov kom tsim nyog. Cov cua kub yuav tsum tau tswj ntawm 40 ° C thiab 50 ° C kom tsis txhob muaj qhov kub thiab txias heev uas ua rau muaj kev hloov pauv hauv cov qauv molecular lossis cov kev hloov pauv hauv cov kua viscosity. Thaum lub sij hawm ua cua sov, nplawm yuav tsum tau txuas ntxiv mus txog thaum HPMC yaj tag.

Txias thiab lim
Tom qab dissolution tiav, cia cov tshuaj kom txias ib txwm mus rau chav tsev kub. Thaum lub sijhawm ua kom txias, me me ntawm npuas lossis impurities yuav tshwm sim hauv cov tshuaj. Yog tias tsim nyog, lub lim tuaj yeem siv los lim nws kom tshem tawm cov khoom ua tau zoo thiab ua kom pom tseeb thiab pom tseeb ntawm cov tshuaj.

Kev kho zaum kawg thiab khaws cia
Tom qab cov tshuaj tau txias, nws cov concentration tuaj yeem hloov kho raws li qhov xav tau tiag tiag. Yog tias qhov concentration siab dhau lawm, ib qho hnyav tuaj yeem ntxiv rau dilute nws; yog tias qhov concentration tsawg dhau, HPMC hmoov yuav tsum tau ntxiv. Tom qab cov tshuaj tau npaj, nws yuav tsum tau siv tam sim ntawd. Yog tias nws yuav tsum tau khaws cia rau lub sijhawm ntev, nws yuav tsum tau muab cia rau hauv lub thawv kaw kom tsis txhob muaj dej evaporation los yog cov kua dej paug.

4. Ceev faj

Kev tswj qhov kub thiab txias: Kev kub siab yuav tsum tau zam thaum lub sij hawm tawg kom tsis txhob cuam tshuam rau kev solubility thiab kev ua haujlwm ntawm AnxinCel®HPMC. Thaum qhov kub thiab txias, HPMC tuaj yeem degrade lossis nws cov viscosity yuav txo qis, cuam tshuam rau nws txoj kev siv.

Stirring txoj kev: Tsis txhob over shearing los yog ceev heev stirring ceev thaum lub sij hawm stirring, vim hais tias muaj zog stirring yuav ua rau npuas tsim thiab cuam tshuam lub pob tshab ntawm cov tshuaj.

Kev xaiv cov kuab tshuaj: Dej yog cov kuab tshuaj ntau tshaj plaws, tab sis hauv qee qhov kev siv tshwj xeeb, kev sib xyaw ntawm cov dej thiab lwm cov kuab tshuaj (xws li cawv, acetone, thiab lwm yam) tuaj yeem xaiv. Qhov sib txawv ntawm cov kuab tshuaj sib txawv yuav cuam tshuam rau tus nqi tawg thiab kev ua haujlwm ntawm cov tshuaj.

Cia tej yam kev mob: Cov tshuaj HPMC npaj yuav tsum tau muab cia rau hauv qhov chaw txias thiab qhuav kom tsis txhob raug mus rau lub sij hawm ntev ntawm kub kub los yog ncaj qha tshav ntuj los tiv thaiv kev hloov nyob rau hauv qhov zoo ntawm cov tshuaj.

Anti-caking: Thaum cov hmoov ntxiv rau cov kuab tshuaj, yog tias cov hmoov ntxiv sai dhau los yog tsis sib xws, nws yooj yim los tsim cov lumps, yog li nws yuav tsum tau maj mam ntxiv.

5. Daim ntawv thov teb

Hydroxypropyl methylcellulose yog dav siv nyob rau hauv ntau yam lag luam vim nws cov dej solubility zoo heev thiab biocompatibility:

Kev lag luam tshuaj: Raws li cov yeeb yaj kiab yav dhau los, cov nplaum nplaum, cov thickener, cov neeg sawv cev tso tawm, thiab lwm yam ntawm cov tshuaj, nws plays lub luag haujlwm tseem ceeb hauv kev npaj cov tshuaj.

Khoom noj khoom haus kev lag luam: Raws li ib tug thickener, emulsifier, stabilizer, nws yog feem ntau siv nyob rau hauv kev ua zaub mov, xws li ice cream, condiments, dej haus, thiab lwm yam.

Kev tsim kho kev lag luam: Raws li cov thickener rau architectural coatings thiab mortar, nws tuaj yeem txhim kho qhov adhesion thiab fluidity ntawm cov sib tov.

Tshuaj pleev ib ce: Raws li ib tug thickener, stabilizer thiab zaj duab xis yav dhau los, nws yog siv nyob rau hauv cov tshuaj pleev ib ce xws li cream, tshuaj zawv plaub hau, thiab cov khoom tu tawv nqaij los txhim kho cov khoom zoo thiab cov neeg siv kev paub.

Kev npaj ntawmHPMCyog ib txheej txheem uas yuav tsum tau saib xyuas kom meej. Thaum lub sij hawm npaj cov txheej txheem, yam xws li kub, stirring txoj kev, thiab hnyav xaiv yuav tsum tau tswj kom paub tseeb tias nws yuav tsum tau tag nrho yaj thiab tuav tau zoo. Los ntawm txoj kev npaj kom raug, AnxinCel®HPMC tuaj yeem siv dav hauv ntau lub lag luam thiab ua nws lub luag haujlwm tseem ceeb.