1. Croscarmellose sodium(cross-linked CMCNa): cross-linked copolymer of CMCNa
Khoom: Dawb los yog tawm-dawb hmoov. Vim yog cov qauv sib txuas, nws yog insoluble hauv dej; Nws swells sai sai hauv dej mus rau 4-8 npaug ntawm nws cov ntim qub. Cov hmoov muaj fluidity zoo.
Daim ntawv thov: Nws yog qhov feem ntau siv super disintegrant. Disintegrant rau qhov ncauj ntsiav tshuaj, ntsiav tshuaj, granules.
2. Carmellose calcium (cross-linked CMCCa):
Khoom: Dawb, tsw ntxhiab hmoov, hygroscopic. 1% tshuaj pH 4.5-6. Yuav luag insoluble hauv ethanol thiab ether hnyav, insoluble hauv dej, insoluble hauv dilute hydrochloric acid, me ntsis soluble hauv dilute alkali. los yog cov hmoov dawb dawb. Vim yog cov qauv sib txuas, nws yog insoluble hauv dej; nws swells thaum nws nqus dej.
Daim ntawv thov: ntsiav tshuaj disintegrant, binder, diluent.
3. Methylcellulose (MC):
Qauv: methyl ether ntawm cellulose
Khoom: Dawb mus rau yellowish dawb hmoov los yog granules. Insoluble hauv dej kub, saturated ntsev tov, cawv, ether, acetone, toluene, chloroform; soluble nyob rau hauv glacial acetic acid los yog sib npaug sib tov ntawm cawv thiab chloroform. Lub solubility nyob rau hauv dej txias yog txuam nrog cov degree ntawm kev hloov, thiab nws yog soluble tshaj plaws thaum lub degree ntawm hloov yog 2.
Daim ntawv thov: ntsiav tshuaj binder, matrix ntawm ntsiav tshuaj disintegrating tus neeg saib xyuas los yog sustained-tso npaj, qab zib los yog gel, suspending agent thiab thickening tus neeg saib xyuas, ntsiav tshuaj txheej, emulsion stabilizer.
4. Ethyl cellulose (EC):
Qauv: Ethyl ether ntawm cellulose
Khoom: Dawb los yog daj-dawb hmoov thiab granules. Insoluble hauv dej, kua hauv plab, glycerol thiab propylene glycol. Nws yog yooj yim soluble nyob rau hauv chloroform thiab toluene, thiab tsim ib tug dawb precipitate nyob rau hauv cov ntaub ntawv ntawm ethanol.
Daim ntawv thov: Cov khoom siv dej-insoluble zoo tagnrho, tsim nyog raws li dej-rhiab tshuaj matrix, dej-insoluble carrier, ntsiav tshuaj binder, zaj duab xis khoom, microcapsule khoom thiab sustained-tso txheej txheej, thiab lwm yam.
5. Hydroxyethyl Cellulose (HEC):
Qauv: Ib nrab hydroxyethyl ether ntawm cellulose.
Khoom: Lub teeb daj los yog mis nyuj dawb hmoov. Soluble nyob rau hauv dej txias, dej kub, tsis muaj zog acid, tsis muaj zog puag, muaj zog acid, muaj zog puag, insoluble nyob rau hauv feem ntau organic solvents (soluble nyob rau hauv dimethyl sulfoxide, dimethylformamide), nyob rau hauv diol polar organic solvents muaj peev xwm nthuav los yog ib nrab yaj.
Daim ntaub ntawv: Cov ntaub ntawv tsis-ionic dej-soluble polymer; thickeners rau ophthalmic npaj, otology thiab tshuaj pleev ib ce; HEC nyob rau hauv lubricants rau qhuav qhov muag, hu rau lo ntsiab muag thiab qhuav qhov ncauj; siv hauv tshuaj pleev ib ce. Raws li ib tug binder, film-forming agent, thickening agent, suspending agent thiab stabilizer rau cov tshuaj thiab zaub mov, nws muaj peev xwm encapsulate cov tshuaj hais, kom cov tshuaj hais yuav ua si ib tug qeeb-tso lub luag hauj lwm.
6. Hydroxypropyl Cellulose (HPC):
Qauv: Ib nrab polyhydroxypropyl ether ntawm cellulose
Khoom: HPC hloov siab yog dawb los yog daj me ntsis hmoov. Soluble nyob rau hauv methanol, ethanol, propylene glycol, isopropanol, dimethyl sulfoxide thiab dimethyl formamide, lub siab viscosity version yog tsawg soluble. Insoluble hauv dej kub, tab sis tuaj yeem o. Thermal gelation: yooj yim soluble hauv dej hauv qab 38 ° C, gelatinized los ntawm cua sov, thiab tsim flocculent o ntawm 40-45 ° C, uas tuaj yeem rov qab los ntawm kev txias.
L-HPC cov yam ntxwv zoo heev: insoluble hauv dej thiab cov kuab tshuaj organic, tab sis swellable hauv dej, thiab cov khoom o tuaj yeem nce ntxiv nrog cov khoom hloov pauv.
Daim ntawv thov: HPC hloov pauv siab yog siv los ua cov ntsiav tshuaj binder, granulating tus neeg sawv cev, cov khoom siv zaj duab xis, thiab tseem tuaj yeem siv los ua cov khoom siv zaj duab xis microencapsulated, cov khoom siv matrix thiab cov khoom siv pabcuam ntawm cov ntsiav tshuaj hauv plab, thickener thiab tiv thaiv colloids, kuj feem ntau siv nyob rau hauv transdermal thaj ua rau thaj.
L-HPC: Feem ntau yog siv los ua cov ntsiav tshuaj disintegrant los yog ib tug binder rau ntub granulation, raws li ib tug sustained-tso ntsiav tshuaj matrix, thiab lwm yam.
7. Hypromellose (HPMC):
Qauv: Ib nrab methyl thiab ib feem polyhydroxypropyl ether ntawm cellulose
Khoom: Dawb los yog tawm-dawb fibrous los yog granular hmoov. Nws yog soluble hauv dej txias, insoluble hauv dej kub, thiab muaj thermal gelation zog. Nws yog soluble hauv methanol thiab ethanol daws, chlorinated hydrocarbons, acetone, thiab lwm yam. Nws solubility hauv cov kuab tshuaj organic zoo dua li dej-soluble.
Daim ntawv thov: Cov khoom no yog cov tshuaj uas tsis muaj viscosity aqueous siv los ua cov khoom siv zaj duab xis txheej; high-viscosity organic solvent tov yog siv los ua cov ntsiav tshuaj binder, thiab cov khoom muaj viscosity siab tuaj yeem siv los thaiv kev tso tawm matrix ntawm cov tshuaj dej-soluble; raws li qhov muag tee thickener rau lacquer thiab cov kua muag dag, thiab tus neeg sawv cev ntub dej rau cov lo ntsiab muag.
8. Hypromellose Phthalate (HPMCP):
Qauv: HMCCP yog phthalic acid ib nrab ester ntawm HPMC.
Khoom: Beige los yog dawb flakes los yog granules. Insoluble nyob rau hauv dej thiab acidic kua, insoluble nyob rau hauv hexane, tab sis yooj yim soluble nyob rau hauv acetone: methanol, acetone: ethanol los yog methanol: chloromethane sib tov.
Daim ntawv thov: Ib hom tshiab txheej txheej nrog kev ua tau zoo heev, uas tuaj yeem siv los ua zaj duab xis txheej los npog cov ntxhiab tsw ntawm cov ntsiav tshuaj lossis granules.
9. Hypromellose Acetate Succinate (HPMCAS):
Structure: Mixed acetic thiab succinic esters ntawmHPMC
Khoom: Dawb mus rau yellowish dawb hmoov los yog granules. Soluble nyob rau hauv sodium hydroxide thiab sodium carbonate tov, yooj yim soluble nyob rau hauv acetone, methanol los yog ethanol: dej, dichloromethane: ethanol sib tov, insoluble nyob rau hauv dej, ethanol thiab ether.
Daim ntawv thov: Raws li ntsiav tshuaj enteric txheej cov ntaub ntawv, sustained tso tawm txheej khoom thiab zaj duab xis txheej khoom.
10. Agar:
Qauv: Agar yog ib qho sib xyaw ntawm tsawg kawg ob polysaccharides, txog 60-80% nruab nrab agarose thiab 20-40% agarose. Agarose yog tsim los ntawm agarobiose rov ua haujlwm nyob rau hauv uas D-galactopyranosose thiab L-galactopyranosose yog sib txuas ntawm 1-3 thiab 1-4.
Khoom: Agar yog translucent, lub teeb daj square cylinder, slender strip los yog scaly flake los yog hmoov. Insoluble nyob rau hauv dej txias, soluble nyob rau hauv boiling dej. Swells 20 zaug hauv dej txias.
Daim ntawv thov: Raws li kev sib khi tus neeg saib xyuas, tshuaj pleev lub hauv paus, suppository puag, emulsifier, stabilizer, tshem tawm tus neeg saib xyuas, kuj yog poultice, capsule, syrup, jelly thiab emulsion.
Post lub sij hawm: Apr-26-2024