Qhov pH yog HPMC soluble

Hydroxypropyl methylcellulose (HPMC)yog ib qho khoom siv polymer feem ntau siv hauv tshuaj, tshuaj pleev ib ce, thiab khoom noj khoom haus. Nws solubility nyob ntawm ntau yam, nrog rau pH. Feem ntau, HPMC yog soluble nyob rau hauv ob qho tib si acidic thiab alkaline tej yam kev mob, tab sis nws solubility yuav sib txawv raws li cov degree ntawm hloov (DS) thiab molecular hnyav (MW) ntawm lub polymer.

Nyob rau hauv acidic tej yam kev mob, HPMC feem ntau pom zoo solubility vim lub protonation ntawm nws hydroxyl pawg, uas txhim khu nws hydration thiab dispersibility. Lub solubility ntawm HPMC nyhav nce raws li pH txo qis hauv nws cov pKa, uas yog nyob ib ncig ntawm 3.5-4.5 nyob ntawm qhov kev hloov pauv.

Hloov pauv, nyob rau hauv cov xwm txheej alkaline, HPMC kuj tuaj yeem ua rau soluble, tshwj xeeb tshaj yog ntawm cov nqi pH siab dua. Ntawm alkaline pH, deprotonation ntawm cov pab pawg hydroxyl tshwm sim, ua rau kom muaj zog solubility los ntawm hydrogen bonding nrog dej molecules.

Txawm li cas los xij, nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias qhov pH pes tsawg uas HPMC yuav ua rau muaj kev sib txawv tuaj yeem sib txawv raws li qib tshwj xeeb ntawm HPMC, nws qib kev hloov pauv, thiab nws qhov hnyav molecular. Feem ntau, HPMC qib nrog qib siab dua ntawm kev hloov pauv thiab qis dua molecular hnyav pom zoo solubility ntawm qis pH qhov tseem ceeb.

Hauv cov tshuaj formulations,HPMCfeem ntau yog siv los ua zaj duab xis qub, thickener, lossis stabilizer. Nws cov yam ntxwv solubility yog qhov tseem ceeb rau kev tswj cov tshuaj tso tawm profiles, viscosity ntawm formulations, thiab stability ntawm emulsions los yog ncua kev kawm ntawv.

thaum HPMC feem ntau yog soluble nyob rau hauv ib tug dav pH ntau yam, nws solubility cwj pwm yuav ua tau zoo-tuned los ntawm kev kho cov pH ntawm cov tshuaj thiab xaiv cov qib tsim nyog ntawm HPMC raws li qhov xav tau daim ntawv thov.