Qhov zoo ntawm cov tshuaj qib HPMC

HPMC hydroxypropyl methyl cellulosetau dhau los ua ib qho ntawm cov khoom siv tshuaj loj tshaj plaws nyob hauv tsev thiab txawv teb chaws, vim tias HPMC muaj qhov zoo uas lwm cov excipients tsis muaj.

1. Dej solubility

Nws yog soluble hauv dej txias hauv qab 40 ℃ lossis 70% ethanol, thiab nws yog qhov yooj yim insoluble hauv dej kub siab tshaj 60 ℃, tab sis nws tuaj yeem gelled.

2. Chemically inert

HPMC yog ib hom non-ionic cellulose ether. Nws cov tshuaj tsis muaj ionic nqi thiab tsis cuam tshuam nrog hlau ntsev los yog ionic organic tebchaw. Yog li ntawd, lwm cov excipients tsis hnov ​​​​mob nrog nws thaum lub sijhawm npaj.

3. Kev ruaj ntseg

Nws yog qhov ruaj khov rau cov kua qaub thiab alkali, thiab tuaj yeem khaws cia rau lub sijhawm ntev ntawm pH 3 ~ 11, thiab nws cov viscosity tsis muaj qhov hloov pauv. Cov tshuaj aqueous ntawm HPMC muaj cov nyhuv anti-mildew thiab tuaj yeem tswj cov viscosity ruaj khov thaum lub sij hawm ntev cia. Cov tshuaj excipients sivHPMCmuaj kev ruaj ntseg zoo dua li cov uas siv cov khoom siv tshuaj (xws li dextrin, starch, thiab lwm yam).

4. Adjustability ntawm viscosity

Qhov sib txawv viscosity derivatives ntawm HPMC tuaj yeem sib xyaw ua ke sib txawv, thiab nws cov viscosity tuaj yeem hloov raws li txoj cai, thiab muaj kev sib raug zoo linear, yog li nws tuaj yeem xaiv raws li qhov xav tau. 2.5 Metabolic inertia HPMC tsis absorbed los yog metabolized hauv lub cev, thiab tsis muab calories, yog li nws yog ib qho kev nyab xeeb excipient rau kev npaj tshuaj. .

5. Kev ruaj ntseg

Nws yog feem ntau xav tiasHPMCyog non-toxic thiab non-irritating khoom.

Pharmaceutical-qib HPMC yog ib qho khoom siv tseem ceeb rau kev tsim cov khoom tsim tawm thiab tswj tau. Nws yog ib qho tshuaj excipient txhawb nqa los ntawm lub xeev rau kev tshawb fawb thiab kev loj hlob, thiab yog nyob rau hauv txoj kab nrog txoj kev loj hlob kev txhawb nqa los ntawm lub teb chaws txoj cai kev lag luam. Pharmaceutical-qib HPMC yog cov khoom siv tseem ceeb rau kev tsim cov tshuaj HPMC cog capsules, suav txog ntau dua 90% ntawm cov khoom siv raw ntawm HPMC cog capsules. Cov tshuaj cog qoob loo tsim muaj qhov zoo ntawm kev nyab xeeb thiab kev nyiam huv, kev siv dav, tsis muaj kev pheej hmoo ntawm kev sib txuas cov tshuaj tiv thaiv, thiab kev ruaj ntseg siab, uas yog raws li cov neeg siv khoom xav tau. Kev nyab xeeb thiab kev huv ntawm cov zaub mov thiab tshuaj yog ib qho tseem ceeb ntawm cov tshuaj thiab cov khoom siv hloov pauv zoo tagnrho rau cov tsiaj gelatin capsules.