Menene rashin amfanin HPMC?

Hydroxypropyl methylcellulose (HPMC)wani sinadari ne na gama gari wanda ake amfani da shi sosai a masana'antu da yawa kamar gini, magunguna, abinci da kayan kwalliya. Duk da haka, kodayake HPMC yana da kyawawan kaddarorin da yawa, irin su kauri, emulsification, ƙirƙirar fim, da tsayayyen tsarin dakatarwa, shima yana da wasu rashin amfani da iyakoki.

1. Matsalolin narkewa

Ko da yake ana iya narkar da HPMC a cikin ruwa da wasu abubuwan kaushi na halitta, zafin jiki yana shafar narkewar sa. Yana narkar da sannu a hankali cikin ruwan sanyi kuma yana buƙatar isassun motsawa don narkewa gaba ɗaya, yayin da zai iya samar da gel a cikin ruwan zafi mai zafi, yana sa ya watse ba daidai ba. Wannan halayyar na iya kawo wasu rashin jin daɗi ga wasu yanayin aikace-aikacen (kamar kayan gini da magunguna), kuma ana buƙatar hanyoyin warwarewa na musamman ko ƙari don haɓaka tasirin rushewa.

2. Yawan tsada

Idan aka kwatanta da wasu na halitta ko roba thickeners, samar da kudin na HPMC ne mafi girma. Saboda tsarin shiri mai rikitarwa, wanda ya ƙunshi matakai masu yawa kamar etherification da tsarkakewa, farashinsa ya fi sauran masu kauri, irin su hydroxyethyl cellulose (HEC) ko carboxymethyl cellulose (CMC). Lokacin da aka yi amfani da shi a kan babban sikelin, abubuwan farashi na iya zama dalili mai mahimmanci don iyakance amfani da shi.

3. Ƙimar pH ya shafa

HPMC yana da kwanciyar hankali mai kyau a ƙarƙashin yanayin pH daban-daban, amma yana iya ƙasƙantar da shi a ƙarƙashin matsanancin yanayin pH (kamar acid mai ƙarfi ko tushe mai ƙarfi), yana shafar tasirin sa mai kauri da daidaitawa. Don haka, ana iya iyakance amfani da HPMC a wasu yanayin aikace-aikacen da ke buƙatar matsananciyar yanayin pH (kamar tsarin ɗaukar sinadarai na musamman).

4. Ƙayyadaddun halittu masu iyaka

Ko da yake ana ɗaukar HPMC a matsayin kayan haɗin gwiwar muhalli, har yanzu yana ɗaukar lokaci mai tsawo kafin a lalata shi gaba ɗaya. A cikin yanayi na halitta, raguwar ƙimar HPMC yana jinkirin, wanda zai iya yin tasiri akan yanayin muhalli. Don aikace-aikacen da ke da manyan buƙatun kariyar muhalli, lalacewar HPMC ƙila ba shine mafi kyawun zaɓi ba.

5. Ƙananan ƙarfin injiniya

Lokacin da aka yi amfani da HPMC azaman kayan fim ko gel, ƙarfin injinsa yana da ƙasa kuma yana da sauƙin karya ko lalacewa. Misali, a cikin masana'antar harhada magunguna, lokacin da ake amfani da HPMC don yin capsules, yana da ƙarancin tauri idan aka kwatanta da capsules na gelatin, kuma matsalar rashin ƙarfi na iya shafar kwanciyar hankali na sufuri da ajiya. A cikin masana'antar gine-gine, lokacin da ake amfani da HPMC azaman mai kauri, kodayake yana iya haɓaka mannewar turmi, yana da iyakataccen gudummawa ga ƙarfin injin na ƙarshe.

6. Hygroscopicity

HPMC yana da ƙayyadaddun ƙimar hygroscopicity kuma cikin sauƙi yana ɗaukar danshi a cikin yanayin zafi mai girma, wanda zai iya shafar aikin sa. Misali, a cikin shirye-shiryen abinci ko magunguna, shayar da danshi na iya haifar da laushin kwamfutar hannu da canje-canje a aikin rarrabuwar kawuna, ta haka yana shafar ingancin ingancin samfurin. Don haka, a lokacin ajiya da amfani, ana buƙatar sarrafa zafi na muhalli don hana ayyukansa lalacewa.

7. Tasiri akan bioavailability

A cikin masana'antar harhada magunguna, ana amfani da HPMC sau da yawa don shirya dorewa-saki ko allunan sarrafawa-saki, amma yana iya shafar yanayin sakin wasu magunguna. Alal misali, ga magungunan hydrophobic, kasancewar HPMC na iya rage yawan rushewar miyagun ƙwayoyi a cikin jiki, ta haka yana rinjayar bioavailability. Sabili da haka, lokacin zayyana nau'ikan magunguna, tasirin HPMC akan sakin magunguna yana buƙatar kimantawa a hankali, kuma ana iya buƙatar ƙarin abubuwan haɓakawa don haɓaka ingancin ƙwayoyi.

8. Thermal kwanciyar hankali

HPMC na iya ƙasƙanta ko canza aiki a yanayin zafi mafi girma. Kodayake HPMC yana da ɗan kwanciyar hankali a cikin kewayon zafin jiki na gabaɗaya, yana iya ƙasƙanta, canza launi, ko tabarbarewar aiki a yanayin zafi da ya wuce 200°C, wanda ke iyakance aikace-aikacen sa a cikin matakan zafin jiki. Misali, a wasu robobi ko sarrafa roba, rashin isasshen zafin zafi na HPMC na iya haifar da raguwar ingancin samfur.

9. Matsaloli masu dacewa tare da sauran sinadaran

A cikin aikace-aikacen ƙira, HPMC na iya mayar da martani mara kyau tare da wasu cationic surfactants ko takamaiman ions ƙarfe, yana haifar da turbidity ko coagulation na maganin. Wannan batun daidaitawa na iya shafar inganci da bayyanar samfurin ƙarshe a wasu aikace-aikace (kamar kayan shafawa, magunguna ko hanyoyin sinadarai), na buƙatar gwajin dacewa da haɓaka ƙira.

Ko da yakeHPMCkayan aiki ne da aka yi amfani da su da yawa tare da kyakkyawan kauri, yin fim da haɓakawa, kuma yana da lahani kamar ƙarancin solubility, tsada mai tsada, ƙayyadaddun biodegradability, ƙarancin ƙarfin injin, ƙarfi hygroscopicity, tasiri akan sakin miyagun ƙwayoyi, da juriya mara kyau. Waɗannan iyakoki na iya shafar aikace-aikacen HPMC a wasu takamaiman masana'antu. Don haka, lokacin zabar HPMC azaman albarkatun ƙasa, ya zama dole a yi la'akari da fa'idodi da rashin amfanin sa da haɓaka shi tare da ainihin bukatun aikace-aikacen.