Hydroxypropyl methylcellulose (HPMC) wani fili ne wanda ba na ionic ruwa mai narkewa ba wanda aka samu ta hanyar gyare-gyaren sinadarai na cellulose na halitta. Ana amfani dashi sosai a cikin abinci, magunguna, kayan kwalliya da masana'antar gini, musamman azaman manne, mai kauri, emulsifier da wakili mai dakatarwa a cikin shirye-shiryen magunguna. A cikin tsarin aikace-aikacen, halayen danko na maganin ruwa na HPMC suna da mahimmanci ga aikin sa a fannoni daban-daban.
1. Tsarin da kaddarorin hydroxypropyl methylcellulose
Tsarin kwayoyin halitta na HPMC ya ƙunshi ƙungiyoyi biyu masu maye gurbin, hydroxypropyl (-CH₂CIKI₃) da kuma methyl (-OCH₃), wanda ya sa ya sami kyakkyawan narkewar ruwa da ikon gyarawa. Sarkar kwayoyin halittar HPMC tana da wani tsayayyen tsari, amma kuma tana iya samar da tsarin cibiyar sadarwa mai girma uku a cikin maganin ruwa, yana haifar da karuwa a cikin danko. Nauyinsa na kwayoyin halitta, nau'in maye da matakin maye gurbinsa (watau matakin hydroxypropyl da maye gurbin methyl na kowace raka'a) suna da tasiri mai mahimmanci akan dankowar maganin.
2. Danko halaye na mai ruwa bayani
Halayen danko na maganin ruwa na HPMC suna da alaƙa da alaƙa da abubuwan kamar haɓaka, nauyin kwayoyin, zazzabi da ƙimar pH na sauran ƙarfi. Gabaɗaya, dankowar maganin ruwa na HPMC yana ƙaruwa tare da haɓakar maida hankali. Dankowar sa yana nuna halayen rheological wanda ba na Newtonian ba, wato, yayin da adadin kuzari ya karu, dankon maganin a hankali yana raguwa, yana nuna wani abu mai laushi mai laushi.
(1) Tasirin natsuwa
Akwai wata dangantaka tsakanin danko na HPMC mai ruwa bayani da maida hankali. Yayin da maida hankali na HPMC ya karu, ana haɓaka hulɗar kwayoyin halitta a cikin maganin ruwa mai ruwa, kuma haɗin kai da haɗin gwiwar sassan kwayoyin halitta suna karuwa, yana haifar da karuwa a cikin danko na maganin. A ƙananan ƙididdiga, danko na maganin ruwa na HPMC yana ƙaruwa a layi tare da karuwa mai yawa, amma a mafi girma da yawa, ci gaban danko na maganin yana da kyau ya zama lebur kuma ya kai ga ƙima.
(2) Tasirin nauyin kwayoyin halitta
Nauyin kwayoyin halitta na HPMC kai tsaye yana rinjayar danko na maganin ruwa. HPMC tare da mafi girma kwayoyin nauyi yana da tsayin kwayoyin sarƙoƙi kuma zai iya samar da mafi hadaddun tsarin cibiyar sadarwa mai girma uku a cikin ruwa bayani, haifar da mafi girma danko. Sabanin haka, HPMC tare da ƙananan nauyin kwayoyin halitta yana da tsarin cibiyar sadarwa mai sauƙi da ƙananan danko saboda guntuwar sassan kwayoyin. Saboda haka, a lokacin da ake ji, yana da matukar muhimmanci a zabi HPMC tare da dace kwayoyin nauyi a cimma manufa danko sakamako.
(3) Tasirin zafin jiki
Zazzabi muhimmin al'amari ne da ke shafar dankowar maganin ruwa na HPMC. Yayin da zafin jiki ya karu, motsi na kwayoyin ruwa yana ƙaruwa kuma dankon maganin yawanci yana raguwa. Wannan shi ne saboda lokacin da zafin jiki ya tashi, 'yancin sarkar kwayoyin halitta na HPMC yana ƙaruwa kuma hulɗar da ke tsakanin kwayoyin halitta ya raunana, don haka rage danko na maganin. Koyaya, martanin HPMC daga batches ko iri daban-daban zuwa zafin jiki na iya bambanta, don haka yanayin zafin jiki yana buƙatar daidaitawa bisa takamaiman buƙatun aikace-aikacen.
(4) Tasirin ƙimar pH
HPMC kanta wani fili ne wanda ba na ionic ba, kuma dankowar maganinta na ruwa yana kula da canje-canje a cikin pH. Ko da yake HPMC yana baje kolin ingantattun halayen danko a cikin acidic ko tsaka-tsakin yanayi, solubility da dankowar HPMC za su yi tasiri a cikin mahallin acidic ko alkaline. Misali, a ƙarƙashin ƙaƙƙarfan acid ko ƙaƙƙarfan yanayin alkaline, ƙwayoyin na HPMC na iya zama ɗan ƙasƙantar da kai, don haka rage ɗankowar maganin ruwa.
3. Rheological bincike na danko halaye na HPMC mai ruwa bayani
A rheological hali na HPMC mai ruwa bayani yawanci nuna wadanda ba Newtonian ruwa halaye, wanda ke nufin cewa ta danko ne ba kawai alaka da dalilai kamar bayani maida hankali da kuma kwayoyin nauyi, amma kuma zuwa karfi kudi. Gabaɗaya magana, a ƙananan ƙarancin ƙarfi, maganin ruwa na HPMC yana nuna ɗanko mafi girma, yayin da ƙimar juzu'i ke ƙaruwa, danƙo yana raguwa. Ana kiran wannan ɗabi'a "Shear thinning" ko "shear thinning" kuma yana da mahimmanci a yawancin aikace-aikace. Alal misali, a cikin fannonin sutura, shirye-shiryen magunguna, sarrafa kayan abinci, da dai sauransu, halayen ɓacin rai na HPMC na iya tabbatar da cewa an kiyaye babban danko yayin aikace-aikacen ƙananan sauri, kuma yana iya gudana cikin sauƙi a ƙarƙashin yanayi mai sauri.
4. Sauran abubuwan da suka shafi danko na HPMC mai ruwa bayani
(1) Tasirin gishiri
Bugu da kari na gishiri solutes (kamar sodium chloride) na iya ƙara danko na HPMC ruwa bayani. Wannan shi ne saboda gishiri na iya haɓaka hulɗar tsakanin kwayoyin halitta ta hanyar canza ƙarfin ionic na maganin, ta yadda kwayoyin HPMC suka samar da mafi ƙarancin tsarin cibiyar sadarwa, don haka ƙara danko. Koyaya, tasirin nau'in gishiri da maida hankali akan danko shima yana buƙatar daidaitawa gwargwadon takamaiman yanayi.
(2) Tasirin sauran addittu
Ƙara wasu additives (kamar surfactants, polymers, da dai sauransu) zuwa maganin ruwa na HPMC zai kuma shafi danko. Alal misali, surfactants na iya rage danko na HPMC, musamman a lokacin da surfactant maida hankali ne high. Bugu da kari, wasu polymers ko barbashi kuma na iya yin hulɗa tare da HPMC kuma su canza kaddarorin rheological na maganin sa.
A danko halaye nahydroxypropyl methylcellulose ruwa bayani suna shafar da yawa dalilai, ciki har da maida hankali, kwayoyin nauyi, zazzabi, pH darajar, da dai sauransu HPMC ruwaye bayani yawanci nuna wadanda ba Newtonian rheological Properties, yana da kyau thickening da karfi thinning Properties, da aka yadu amfani a daban-daban masana'antu da Pharmaceutical filayen. Fahimtar da ƙwarewar waɗannan halayen danko zai taimaka inganta amfani da HPMC a aikace-aikace daban-daban. A aikace-aikace masu amfani, yakamata a zaɓi nau'in HPMC da ya dace da yanayin tsari bisa ga takamaiman buƙatu don samun ingantacciyar danko da kaddarorin rheological.
Lokacin aikawa: Maris-01-2025