Hydroxypropyl Methylcellulose (HPMC)polymer ce mai narkewar ruwa da aka saba amfani da ita a cikin masana'antar harhada magunguna, kayan kwalliya da masana'antar abinci. Saboda kyakkyawar solubility na ruwa da kaddarorin daidaitawar danko, ana amfani da HPMC sosai a cikin gels, nau'ikan nau'ikan sakin da aka sarrafa na miyagun ƙwayoyi, dakatarwa, masu kauri da sauran filayen. Daban-daban iri da ƙayyadaddun bayanai na HPMC suna da jeri daban-daban na zafin jiki, musamman lokacin shirya gels na HPMC, zafin jiki yana da tasiri mai mahimmanci akan solubility, danko da kwanciyar hankali.
HPMC narkar da gel samuwar zazzabi kewayon
Yanayin zafin jiki
Yawancin lokaci ana narkar da HPMC a cikin ruwa tare da ruwan zafi, kuma yawan zafin jiki na narkewa ya dogara da nauyin kwayoyinsa da digiri na methylation da hydroxypropylation. Gabaɗaya magana, yanayin zafi na narkar da HPMC ya tashi daga 70 ° C zuwa 90 ° C, kuma takamaiman yanayin zafi yana shafar ƙayyadaddun HPMC da tattarawar maganin. Misali, HPMC mai ƙarancin danko yakan narke a ƙananan zafin jiki (kimanin 70°C), yayin da babban danko na HPMC na iya buƙatar ƙarin zafin jiki (kusa da 90°C) don narke gaba ɗaya.
Zazzabi Samuwar Gel (Zazzabi na Gelation)
HPMC yana da kayan gel na musamman na thermoreversible, wato, zai samar da gel a cikin kewayon zafin jiki. Matsakaicin zafin jiki na gel na HPMC ya fi shafar nauyin kwayoyin sa, tsarin sinadarai, maida hankali na bayani da sauran abubuwan da ake buƙata. Gabaɗaya magana, kewayon zazzabi na gel na HPMC yawanci shine 35 ° C zuwa 60 ° C. A cikin wannan kewayon, sarƙoƙin ƙwayoyin ƙwayoyin cuta na HPMC za su sake tsarawa don samar da tsarin cibiyar sadarwa mai girma uku, yana haifar da sauyawa daga yanayin ruwa zuwa yanayin gel.
Za'a iya tantance takamaiman zazzabi na samuwar gel (watau zazzabin gelation) ta gwaji. Matsakaicin zafin jiki na gel na HPMC yawanci ya dogara da dalilai masu zuwa:
Nauyin kwayoyin halitta: HPMC tare da babban nauyin kwayoyin zai iya samar da gel a ƙananan zafin jiki.
Maganganun Magani: Mafi girman maida hankali na maganin, ƙananan yanayin samuwar gel yawanci.
Digiri na methylation da digiri na hydroxypropylation: HPMC tare da babban digiri na methylation yawanci yana samar da gel a ƙananan zafin jiki saboda methylation yana ƙara hulɗar tsakanin kwayoyin halitta.
Tasirin zafin jiki
A aikace-aikace masu amfani, zafin jiki yana da tasiri mai mahimmanci akan aiki da kwanciyar hankali na gel HPMC. Maɗaukakin yanayin zafi yana ƙara haɓakar sarƙoƙi na ƙwayoyin ƙwayoyin cuta na HPMC, ta haka yana shafar rigidity da halaye na gel. Akasin haka, ƙananan zafin jiki na iya raunana hydration na gel na HPMC kuma ya sa tsarin gel ba shi da tabbas. Bugu da ƙari, canje-canjen zafin jiki na iya haifar da hulɗa tsakanin kwayoyin HPMC da canje-canje a cikin danko na maganin.
Halin gelation na HPMC a pH daban-daban da ƙarfin ionic
Halin gelation na HPMC yana shafar ba kawai ta zafin jiki ba, har ma da pH da ƙarfin ionic bayani. Misali, solubility da gelation hali na HPMC a daban-daban pH dabi'u zai zama daban-daban. Za a iya rage solubility na HPMC a cikin yanayin acidic, yayin da za a iya ƙara ƙarfinsa a cikin mahallin alkaline. Hakazalika, haɓaka ƙarfin ionic (kamar ƙarar gishiri) zai shafi hulɗar tsakanin kwayoyin HPMC, ta haka canza samuwar gel da kwanciyar hankali.
Aikace-aikacen gel na HPMC da halayen zafin sa
Halayen zafin jiki na gel na HPMC sun sanya shi amfani da shi sosai a cikin sakin ƙwayoyi, shirye-shiryen kwaskwarima da sauran filayen:
Sakin magani da aka sarrafa
A cikin shirye-shiryen miyagun ƙwayoyi, ana amfani da HPMC sau da yawa azaman matrix mai sarrafawa, kuma ana amfani da kaddarorin sa na gelation don daidaita yawan sakin kwayoyi. Ta hanyar daidaita maida hankali da zazzabi na gelation na HPMC, ana iya sarrafa sakin kwayoyi daidai. Canjin zazzabi na kwayoyi a cikin sashin gastrointestinal na iya haɓaka kumburin gel na HPMC da sakin magunguna a hankali.
Kayan shafawa da Kayayyakin Kulawa na Kai
Ana amfani da HPMC da yawa a cikin kayan kwalliya kamar kayan shafawa, gels, feshin gashi, da man shafawa na fata. Saboda yanayin zafinsa, HPMC na iya daidaita rubutu da kwanciyar hankali na samfuran ƙarƙashin yanayin zafi daban-daban. Canje-canjen yanayin zafi a cikin abubuwan kwaskwarima suna da tasiri mai mahimmanci akan halayen gelation na HPMC, don haka ana buƙatar zaɓin takamaiman ƙayyadaddun HPMC da suka dace yayin zayyana samfuran.
Masana'antar Abinci
A cikin abinci, ana amfani da HPMC sosai azaman mai kauri da emulsifier, musamman a cikin shirye-shiryen abinci da abubuwan sha. Abubuwan da ke da zafin zafinsa suna ba HPMC damar canza yanayin jikinta yayin dumama ko sanyaya, ta haka yana shafar dandano da tsarin abinci.
The zafin jiki Properties naHPMCgels sune mabuɗin mahimmanci a aikace-aikacen su. Ta hanyar daidaita yanayin zafi, maida hankali, da gyare-gyaren sinadarai, kayan aikin gels na HPMC, irin su solubility, ƙarfin gel, da kwanciyar hankali, ana iya sarrafa su daidai. Yawan zafin jiki na gel yakan kasance tsakanin 35 ° C da 60 ° C, yayin da kewayon zafinsa na narkewa gaba ɗaya shine 70 ° C zuwa 90 ° C. Ana amfani da HPMC ko'ina a cikin masana'antar harhada magunguna, kayan kwalliya, da masana'antar abinci saboda keɓancewar halayen gelation ɗin sa na thermoreversible da yanayin zafin jiki.
Lokacin aikawa: Janairu-16-2025