Hydroxypropyl methylcellulosewani nau'i ne na cellulose wanda ba na ionic ba. Ba kamar ionic methyl carboxymethyl cellulose gauraye ether, shi ba ya amsa da nauyi karafa. Saboda daban-daban rabo na methoxyl abun ciki da hydroxypropyl abun ciki a hydroxypropyl methylcellulose da daban-daban viscosities, akwai da yawa iri da daban-daban kaddarorin, misali, high methoxyl abun ciki da low hydroxypropyl abun ciki Its yi yana kusa da na methyl cellulose, yayin da yi na low methoxyl abun ciki da kuma high hydroxypropyl abun ciki na cellulose. Koyaya, a cikin kowane iri-iri, kodayake ƙaramin rukunin hydroxypropyl ko ƙaramin ƙungiyar methoxyl yana ƙunshe, akwai babban bambance-bambance a cikin solubility a cikin kaushi na ƙwayoyin cuta ko yanayin zafi a cikin mafita mai ruwa.
(1) Abubuwan solubility na hydroxypropyl methylcellulose
① Solubility na hydroxypropyl methylcellulose a cikin ruwaHydroxypropyl methylcelluloseshine ainihin nau'in methylcellulose wanda aka gyara ta hanyar propylene oxide (methoxy-propylene), don haka har yanzu yana da kaddarorin iri ɗaya kamar yadda methyl cellulose yana da irin wannan halaye na narkewar ruwan sanyi da rashin narkewar ruwan zafi. Duk da haka, saboda ƙungiyar hydroxypropyl da aka gyara, yawan zafin jiki na gelation a cikin ruwan zafi ya fi girma fiye da na methyl cellulose. Misali, danko na hydroxypropyl methylcellulose mai ruwa bayani tare da 2% methoxy abun ciki maye digiri DS=0.73 da hydroxypropyl abun ciki MS=0.46 ne 500mpa·s a 20 ° C, da gel zazzabi Yana iya isa kusa da 100 ° C, yayin da methyl cellulose ne kawai game da 5 ° C. Dangane da narkewar sa a cikin ruwa, shi ma an inganta shi sosai. Misali, za'a iya siyan hydroxypropyl methylcellulose da aka niƙa (siffar granular 0.2 ~ 0.5mm a 20 ° C tare da 4% dankowar maganin ruwa na 2pa• s a dakin da zafin jiki, yana da sauƙin narkewa cikin ruwa ba tare da sanyaya ba.
② Solubility na hydroxypropyl methylcellulose a cikin kwayoyin kaushi na kwayoyin halitta na hydroxypropyl methylcellulose a cikin kwayoyin halitta kuma ya fi na methylcellulose kyau. Methylcellulose yana buƙatar samun digiri na maye gurbin methoxyl na 2.1 Abubuwan da ke sama, amma dauke da hydroxypropyl MS = 1.5 ~ 1.8 da methoxy DS = 0.2 ~ 1.0, babban danko hydroxypropyl methylcellulose tare da jimlar digiri na maye gurbin sama da 1.8 an narkar da shi a cikin ruwa mai ruwa da ruwa mai ruwa da ruwa mai ruwa da ruwa mai ruwa da ruwa. narkewa. Hakanan yana narkewa a cikin chlorinated hydrocarbons kamar methylene chloride da chloroform, da sauran kaushi kamar acetone, isopropanol da diacetone barasa. Solubility a cikin kwayoyin kaushi yana da kyau fiye da solubility na ruwa.
(2) Abubuwan Tasirin Dankowar Hydroxypropyl Methyl Cellulose Daidaitaccen ƙaddarar danko na hydroxypropyl methyl cellulose daidai yake da na sauran ethers cellulose. Ana auna shi a 20 ° C tare da maganin ruwa na 2% a matsayin ma'auni. Danko na samfurin iri ɗaya yana ƙaruwa tare da haɓaka haɓaka. Don samfurori tare da sikelin kwayoyin halitta daban-daban a daidai maida hankali, samfurin tare da babban nauyin kwayoyin yana da danko. Alakarsa da zafin jiki yayi kama da na methyl cellulose. Lokacin da zafin jiki ya tashi, danko ya fara raguwa, amma lokacin da ya kai wani zafin jiki, danko ya tashi ba zato ba tsammani kuma gelation yana faruwa. Zazzabi gel na samfuran ƙarancin danko ya fi girma. yana da girma. Ma'anar gel ɗin sa ba wai kawai yana da alaƙa da danko na ether ba, har ma yana da alaƙa da rabon abun ciki na ƙungiyar metoxyl da ƙungiyar hydroxypropyl a cikin ether da girman jimlar digirin maye gurbin. Dole ne a lura cewa hydroxypropyl methylcellulose shima pseudoplastic ne, kuma maganin sa yana da ƙarfi a cikin zafin jiki ba tare da wani lahani na ɗanko ba sai don yuwuwar lalatawar enzymatic.
(3) Haƙurin gishiri na hydroxypropyl methylcellulose Tunda hydroxypropyl methylcellulose ba shi da ether, ba a ionized a cikin kafofin watsa labaru na ruwa, sabanin sauran ionic cellulose ethers, irin su carboxymethyl Base cellulose, a cikin bayani don amsawa tare da ions karfe mai nauyi da hazo. Gabaɗaya gishiri irin su chloride, bromide, phosphate, nitrate, da dai sauransu ba za su yi hazo ba idan aka haɗa su da ruwa mai ruwa. Koyaya, ƙari na gishiri yana da ɗan tasiri akan yanayin zafi na flocculation maganin ruwa. Lokacin da gishiri gishiri ya karu, yawan zafin jiki na gel yana raguwa. Lokacin da maida hankali gishiri ya kasance ƙasa da wurin flocculation, danko na maganin yana ƙoƙarin ƙarawa. Saboda haka, an ƙara wani adadin gishiri, a cikin aikace-aikacen, zai iya samun sakamako mai girma a cikin tattalin arziki. Sabili da haka, a wasu aikace-aikace, yana da kyau a yi amfani da cakuda ether cellulose da gishiri fiye da babban taro na ether bayani don cimma sakamako mai girma.
(4) Hydroxypropyl methylcellulose acid da juriya na alkali Hydroxypropyl methylcellulose gabaɗaya ba su da ƙarfi ga acid da alkalis, kuma ba a shafa su cikin kewayon pH 2 ~ 12. Yana iya jure wani adadin haske, Irin su formic acid, acetic acid, citric acid, succinic acid, phosphoric acid, boric acid, da sauransu. Alkalai irin su caustic soda, caustic potash da ruwan lemun tsami ba su da wani tasiri a kai, amma suna iya kara dankowar maganin, sannan a rage shi a hankali.
(5) Rashin daidaituwa na hydroxypropyl methylcellulose Hydroxypropyl methylcellulose mafita za a iya haɗe shi da ruwa mai narkewa polymer mahadi don zama uniform da m bayani tare da mafi girma danko. Wadannan mahadi na polymer sun hada da polyethylene glycol, polyvinyl acetate, polysilicon, polymethylvinyl siloxane, hydroxyethyl cellulose, da methyl cellulose. Haɗaɗɗen maɗaukakin ƙwayoyin halitta irin su gumakan arabic, ɗan waken fari, karaya danko, da dai sauransu suma suna da dacewa sosai tare da maganin sa. Hydroxypropyl methylcellulose kuma ana iya haɗa shi da mannitol ester ko sorbitol ester na stearic acid ko palmitic acid, kuma ana iya haɗa shi da glycerin, sorbitol da mannitol, kuma ana iya amfani da waɗannan mahadi azaman hydroxypropyl methylcellulose Plasticizer don cellulose.
(6) Ruwan da ba ya narkewacellulose ethersna hydroxypropyl methylcellulose na iya aiwatar da haɗin giciye tare da aldehydes, don haka waɗannan ethers masu narkewar ruwa suna haɓaka a cikin maganin kuma su zama marasa narkewa a cikin ruwa. Aldehydes da ke yin hydroxypropyl methylcellulose insoluble sun hada da formaldehyde, glyoxal, succinic aldehyde, adipaldehyde, da dai sauransu Lokacin amfani da formaldehyde, ya kamata a biya kulawa ta musamman ga darajar pH na maganin, wanda glioxal ke amsawa, don haka ana amfani da glioxal a matsayin wakili mai sauri. Matsakaicin nau'in nau'in nau'in nau'in haɗin kai a cikin maganin shine 0.2% ~ 10% na yawan adadin ether, zai fi dacewa 7% ~ 10%, misali, 3.3% ~ 6% na glioxal shine mafi dacewa. Gabaɗaya, zafin magani shine 0 ~ 30 ℃, kuma lokacin shine 1 ~ 120min. Ana buƙatar aiwatar da halayen haɗin kai a ƙarƙashin yanayin acidic. Gabaɗaya, ana daidaita pH na maganin zuwa kusan 2 ~ 6 ta hanyar ƙara inorganic acid mai ƙarfi ko Organic carboxylic acid zuwa maganin, zai fi dacewa tsakanin 4 ~ 6, sa'an nan kuma ana ƙara aldehydes don aiwatar da halayen haɗin gwiwa. Acid da aka yi amfani da shi yana da hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, hydroxy-acetic acid, succinic acid ko citric acid da dai sauransu, inda tare da formic acid ko acetic acid yana da kyau, kuma formic acid shine mafi kyau duka. Hakanan za'a iya ƙara acid da aldehyde a lokaci guda don ba da damar maganin ya sami hanyar haɗin kai a cikin kewayon pH da ake so. Ana amfani da wannan amsa sau da yawa a cikin tsarin jiyya na ƙarshe a cikin tsarin shirye-shiryen ethers cellulose. Bayan ether cellulose ba shi da narkewa, ya dace don amfani.
20 ~ 25 ℃ ruwan wanka da tsarkakewa. Lokacin da ake amfani da samfurin, ana iya ƙara abubuwan alkaline zuwa maganin samfurin don daidaita pH na maganin ya zama alkaline, kuma samfurin zai narke a cikin bayani da sauri. Hakanan ana amfani da wannan hanyar don maganin fim ɗin bayan an yi maganin ether cellulose a cikin fim don sanya shi fim ɗin da ba zai iya narkewa ba.
(7) Enzyme juriya na hydroxypropyl methylcellulose ne a ka'idar cellulose abubuwan, kamar kowane anhydroglucose kungiyar, idan akwai da tabbaci bonded substituent kungiyar, shi ne ba sauki a kamuwa da microorganisms, amma a gaskiya da ƙãre samfurin Lokacin da musanya darajar wuce 1, shi ma za a kaskanta da cewa sarkar da wani mataki na wani rukuni na substituents, amma a gaskiya ma, za a kaskanta da sarkar da wani rukuni na enzymes. isa, kuma ƙananan ƙwayoyin cuta na iya lalata ƙungiyar anhydroglucose da ba a maye gurbin su ba don samar da sukari, azaman abubuwan gina jiki don ƙwayoyin cuta su sha. Saboda haka, idan matakin etherification maye gurbin cellulose ya karu, juriya ga enzymatic yashwa na cellulose ether kuma zai karu. A cewar rahotanni, a ƙarƙashin yanayin sarrafawa, sakamakon hydrolysis na enzymes da aka yi, ragowar danko na hydroxypropyl methylcellulose (DS=1.9) shine 13.2%, methylcellulose (DS = 1.83) shine 7.3%, methylcellulose (DS=1.66) shine 3.8% cell, hydroxy . Ana iya ganin cewa hydroxypropyl methylcellulose yana da ƙarfin anti-enzyme mai ƙarfi. Saboda haka, mafi kyaun enzyme juriya na hydroxypropyl methylcellulose, haɗe tare da mai kyau dispersibility, thickening da film-forming Properties, ana amfani da ruwa-emulsion coatings, da dai sauransu, kuma kullum ba ya bukatar ƙara preservatives. Duk da haka, don adana dogon lokaci na bayani ko yiwuwar gurɓata daga waje, za'a iya ƙara abubuwan kiyayewa a matsayin kariya, kuma za'a iya ƙayyade zaɓin bisa ga bukatun ƙarshe na bayani. Phenylmercuric acetate da manganese fluorosilicate suna da tasiri masu mahimmanci, amma duk suna da guba, dole ne a biya hankali ga aikin. Gabaɗaya, ana iya ƙara 1 ~ 5mg na phenylmercury acetate zuwa maganin kowace lita na sashi.
(8) Aiki nahydroxypropyl methylcellulosefim ɗin Hydroxypropyl methylcellulose yana da kyawawan abubuwan ƙirƙirar fim. Maganin ruwan sa ko maganin kaushi na halitta ana lullube shi akan farantin gilashi, kuma ya zama mara launi da bayyane bayan bushewa. Kuma fim mai tauri. Yana da juriya mai kyau da danshi kuma ya kasance mai ƙarfi a yanayin zafi mai yawa. Idan an ƙara hygroscopic plasticizer, za a iya inganta elongation da sassauci. Dangane da inganta sassauci, masu yin filastik irin su glycerin da sorbitol sun fi dacewa. Gabaɗaya, ƙaddamarwar maganin shine 2% ~ 3%, kuma adadin filastik shine 10% ~ 20% na ether cellulose. Idan abun ciki na filastikizer ya yi yawa, raguwar bushewar colloidal zai faru a babban zafi. Ƙarfin ƙarfin fim ɗin tare da filastik da aka ƙara ya fi girma fiye da haka ba tare da filastik ba, kuma yana ƙaruwa tare da ƙara yawan adadin. Amma ga hygroscopicity na fim din, yana ƙaruwa tare da ƙara yawan adadin filastik.
Lokacin aikawa: Afrilu-25-2024